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The authors established FOXO4-DRI as a first-in-class senolytic peptide tool for cellular senescence research, with mechanistic selectivity grounded in the elevated FOXO4-p53 interaction in senescent versus non-senescent cells

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In addition, maternal consumption of caffeine during gestation (26 and 45 mg/kg) and lactation (25 and 35 mg/kg) was shown to also negatively affect male reproductive function in the male offspring rats as indicated by a significant reduction in testicular weight, diameter and epithelial heights of seminiferous tubules, testosterone production and sperm quality 66

He wrote that 38 "chronic alcoholics" had reportedly suffered liver and/or kidney damage while taking acetaminophen